Ghrelin

The hormone Ghrelin lies in the middle of several important metabolic and mental processes

Positive feedback isn’t always a good thing, especially when it comes to the hormones that govern appetite.

We’ve talked a little bit here before about leptin and ghrelin, the two hormones that regulate energy balance by way of appetite. Leptin mediates energy levels by suppressing appetite, but when the body is in need of energy, it produces ghrelin as the primary trigger to seek out energy-dense foods.[1]

Even a minor disturbance in this natural cycle can potentially start a destructive positive feedback loop, however. Both overproduction of ghrelin and suppression of leptin can make you feel like you’re always half-starved, even when you don’t really need any further nutrition whatsoever. What’s worse, this hormonal trigger will make the worst possible foods — salty, sugary and high in unhealthy saturated fat — seem like the most appealing.

Ghrelin research is new but very helpful

Studies of these hormones are in their relative infancy, and their exact function isn’t well understood yet, particularly as they relate to weight gain and obesity. As we talked about here previously, it’s now known to science that acute sleep deprivation leads to increased cravings for snacks between meals, larger portion sizes and a preference for energy-dense foods.[2]

Poor diet decisions go beyond sleep, though

But it’s also thought that leptin and ghrelin aren’t the primary motivators when lack of sleep is a factor. When you take sleep out of the equation and just focus on hormonal imbalances in otherwise healthy adults, however, studies thus far show that the two operate in a delicate balance that can be easy to throw out of whack with poor eating habits.

For example, one 2004 study of women with a healthy body weight showed that consumption of high-fructose corn syrup led to a decrease of circulating insulin and leptin and an increase in ghrelin levels as opposed to consumption of glucose.[3]

Over the long term, suppression of leptin may lead to an ongoing resistance to it.[1,5]

Does ghrelin start the hunger problem, or just continue it?

The Ghrelin Pathway

In certain eating disorders, ghrelin’s pathways are activated in only survival conditions. This is nearly the opposite of overweight users, when ghrelin is activated too often.

Here the issue becomes more of a “chicken or the egg” question that research hasn’t yet settled — it’s not clear if a range of other mechanisms that contribute to weight gain are also chronically disrupting the leptin-ghrelin balance, or if it’s a sustained disturbance of the balance that kicks off and feeds some of these mechanisms.[6]

Unfortunately, even if you’re doing everything right, you may still experience a natural ghrelin spike as a consequence of losing weight due to caloric restriction. Studies have shown that getting enough clean carbohydrates to meet your macronutrient needs and a focus on lowering dietary fat seems to produce very little increase in appetite even when overall calories are reduced.[4] So much for those no-carb diets!

The layman’s conclusion

Fact is, if you’re significantly overweight, it took years to throw these hormones out of balance, and it could potentially take years to fix them too. Fighting cravings along the way is not going to be fun.

If you want your diet to work, you’re going to need to put serious time and work into it, trust your food scale, and be insanely consistent.

We hate to say it, but that’s just the state of the situation. Surgery can’t solve these problems. Quick cleanses can’t solve these problems. Hard work and dedication can — and they’re worth doing — to live a better life.

Pyroxamine can help

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If you’re craving food when you know you no longer need to eat, Myokem Pyroxamine can intervene in a number of ways.

First, there’s appetite suppression to crush cravings. Carralluma fimbriata, bacopa monniera, olive leaf extract and evodia rutaecarpa are all natural extracts that work synergistically to regulate food intake.

Meanwhile, the High Energy Matrix helps you to push through those sluggish slumps without turning to unhealthy foods and sugary “energy drinks.”

You can read more on the homepage of this site, and request a free sample and see the difference for yourself!

But once again, Pyroxamine can only help, it is not going to do the hard work for you.

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